Description

1-Piperidinecarboxylic Acid, 3-[(R)-(3-Chlorophenyl)[2-[(Methoxycarbonyl)Amino]Ethoxy]Methyl]-, 1,1-Dimethylethyl Ester, (3R)- is a sophisticated chiral piperidine derivative, serving as a critical advanced pharmaceutical intermediate. Its complex molecular architecture, featuring a 3-chlorophenyl group and a protected aminoethoxy side chain, makes it a valuable building block for the synthesis of targeted active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development organizations and pharmaceutical manufacturers engaged in creating novel therapeutic agents, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) or other specialized therapeutic areas.
• API Synthesis: Used as a critical building block for constructing the core scaffold or side chains of potential new chemical entities (NCEs) in medicinal chemistry.
• Process Research & Development (R&D): Employed in route scouting, optimization studies, and scale-up activities for new drug development pipelines.
• Asymmetric Synthesis: Leverages its defined (3R)- stereochemistry to introduce chirality into target molecules, which is crucial for the efficacy and safety profile of many modern pharmaceuticals.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for the cGMP production of clinical trial materials or commercial APIs.
• Academic & Institutional Research: Utilized in university and institutional labs for pharmacological studies and the development of new synthetic methodologies.

Basic Information

Item	Details
Product Name	1-Piperidinecarboxylic Acid, 3-[(R)-(3-Chlorophenyl)[2-[(Methoxycarbonyl)Amino]Ethoxy]Methyl]-, 1,1-Dimethylethyl Ester, (3R)-
CAS No.	942142-79-2
Molecular Formula	C21H31ClN2O5
Molecular Weight	426.94 g/mol
Synonyms	(3R)-3-[(R)-(3-Chlorophenyl)(2-[(methoxycarbonyl)amino]ethoxy)methyl]-1-(tert-butoxycarbonyl)piperidine; tert-Butyl (3R)-3-[(R)-(3-chlorophenyl)(2-[(methoxycarbonyl)amino]ethoxy)methyl]piperidine-1-carboxylate; (R)-tert-Butyl 3-((R)-(3-chlorophenyl)(2-((methoxycarbonyl)amino)ethoxy)methyl)piperidine-1-carboxylate; BOC-Protected 3R-Chloro Intermediates; CAS 942142-79-2; 1-Boc-3-[(R)-(3-chlorophenyl)(2-[(methoxycarbonyl)amino]ethoxy)methyl]piperidine, (3R)-; Advanced Chiral Piperidine Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical development. Quality is verified through comprehensive analytical methods including HPLC, GC, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity (typically >98.5%), chiral purity, and impurity profiles is provided with each batch. We support development with customized specifications to meet the specific needs of your API synthesis pathway.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen) for extended storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.