Description

(3R,5S)-tert-Butyl 3,4,5-Trimethylpiperazine-1-Carboxylate is a high-purity, stereochemically defined piperazine derivative used as a critical chiral building block in advanced organic synthesis. Its precise stereochemistry and protected amine functionality make it an essential intermediate for the development of complex, biologically active molecules. This compound is primarily targeted at pharmaceutical R&D and fine chemical manufacturers requiring reliable, high-quality intermediates for API synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and amine functionality into candidate drug molecules.
• Asymmetric Synthesis: Serves as a chiral auxiliary or a starting material for the synthesis of other enantiomerically pure compounds in fine chemical production.
• Peptidomimetics & Scaffold Development: The piperazine core is utilized to construct conformationally constrained scaffolds for drug discovery programs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and catalysis.

Basic Information

Product Name	(3R,5S)-tert-Butyl 3,4,5-Trimethylpiperazine-1-Carboxylate
CAS No.	942125-59-9
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	1-BOC-(3R,5S)-3,4,5-Trimethylpiperazine; tert-Butyl (3R,5S)-3,4,5-trimethylpiperazine-1-carboxylate; (3R,5S)-1-N-Boc-3,4,5-trimethylpiperazine; 1-(tert-Butoxycarbonyl)-(3R,5S)-3,4,5-trimethylpiperazine; Boc-3,4,5-trimethylpiperazine (3R,5S)-isomer; Piperazine-1-carboxylic acid, 3,4,5-trimethyl-, 1,1-dimethylethyl ester, (3R,5S)-
EINECS	Contact for details

Quality Control

Our (3R,5S)-tert-Butyl 3,4,5-Trimethylpiperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical development. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.