Description

4-Acetyl-Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of novel pharmaceutical candidates, particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in neuropharmacology.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery projects.
• Peptidomimetics: Serves as a constrained scaffold or backbone element in the design of peptide mimics.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and probes for studying biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocycle synthesis.

Basic Information

Product Name	4-Acetyl-Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	939997-63-4
Molecular Formula	C13H22N2O5
Molecular Weight	286.33 g/mol
Synonyms	1-tert-Butyl 2-(4-acetylpiperazine-1,2-dicarboxylate); 1-(tert-Butoxycarbonyl)-4-acetylpiperazine-2-carboxylic Acid; 4-Acetyl-1-Boc-piperazine-2-carboxylic Acid; 1-Boc-4-acetylpiperazine-2-carboxylic Acid; 4-Acetylpiperazine-1,2-dicarboxylic Acid 1-tert-Butyl Ester; N-Boc-4-acetylpiperazine-2-carboxylic Acid; (2S)-4-Acetyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic Acid (for stereoisomer); Protected 4-Acetylpiperazine-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 4-Acetyl-Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.