Description

4-(2-Chloro-Thiazol-5-Ylmethoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity (98+%) advanced pharmaceutical intermediate with the molecular formula C14H21ClN2O3S and a molecular weight of 332.85. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing piperidine-thiazole based molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the thiazole moiety.
• Chemical Biology Probe: Serves as a precursor for labeled compounds or molecular probes used in target identification and validation studies.
• Process Chemistry: Employed in route scouting and optimization for scalable API manufacturing under GMP-like conditions.
• Custom Synthesis: Foundation for contract research organizations (CROs) and CDMOs to create bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development and studying heterocyclic chemistry.

Basic Information

Item	Details
Product Name	4-(2-Chloro-Thiazol-5-Ylmethoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	939986-56-8
Molecular Formula	C14H21ClN2O3S
Molecular Weight	332.85 g/mol
Synonyms	1-Boc-4-[(2-chloro-1,3-thiazol-5-yl)methoxy]piperidine; tert-Butyl 4-[(2-chloro-1,3-thiazol-5-yl)methoxy]piperidine-1-carboxylate; 4-[(2-Chloro-1,3-thiazol-5-yl)methoxy]piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(2-chlorothiazol-5-yl)methoxy]piperidine; BOC-4-[(2-Chlorothiazol-5-yl)methoxy]piperidine; 4-(2-Chloro-thiazol-5-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Thiazol-5-Ylmethoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity and purity exceeding 98%. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality system supports development under ISO 9001 guidelines, and we can accommodate specific analytical requirements for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.