Description

(S)-3-(tert-Butyldimethylsilyloxy)Piperidin-2-One is a high-purity, chiral piperidinone derivative protected with a tert-butyldimethylsilyl (TBDMS) group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in the synthesis of complex bioactive molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for constructing nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in neurologic and psychotropic drug candidates.
• Asymmetric Synthesis: Used as a chiral precursor in stereoselective reactions to introduce the (S)-configured piperidinone scaffold.
• Medicinal Chemistry Research: A versatile building block for constructing compound libraries in drug discovery programs targeting GPCRs and enzymes.
• Agrochemical Synthesis: Intermediate in the production of enantiomerically pure agrochemicals, such as herbicides and fungicides.
• Fine Chemical Production: Employed in the multi-step synthesis of complex natural products and specialty chemicals.
• Protecting Group Chemistry: The TBDMS-protected hydroxyl group allows for selective deprotection and further functionalization in complex synthetic routes.

Basic Information

Product Name	(S)-3-(tert-Butyldimethylsilyloxy)Piperidin-2-One
CAS No.	937740-20-0
Molecular Formula	C11H23NO2Si
Molecular Weight	229.40 g/mol
Synonyms	(S)-3-[(tert-Butyldimethylsilyl)oxy]-2-piperidinone; (S)-3-(Tert-Butyldimethylsiloxy)piperidin-2-one; (S)-3-(TBDMSO)piperidin-2-one; 2-Piperidinone, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3S)-; (3S)-3-[(tert-Butyldimethylsilyl)oxy]piperidin-2-one; (S)-3-(tert-Butyldimethylsilyloxy)-2-piperidone; (S)-N-Boc-3-(TBDMS-oxy)piperidin-2-one (common precursor name); TBDMS-protected (S)-3-hydroxypiperidin-2-one
EINECS	Contact for details

Quality Control

Our (S)-3-(tert-Butyldimethylsilyloxy)Piperidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards for research and production. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.