Description

Ho-Peg8-Ch2Ch2Cooh CAS NO 937188-60-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group at one terminus and a carboxylic acid group at the other, linked by an 8-unit PEG spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of bioactive molecules, polymers, or surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating PEGylated therapeutics, drug delivery systems, and functionalized hydrogels.

Application

• Bioconjugation Linker: Used to covalently attach drugs, peptides, or proteins to nanoparticles, surfaces, or other polymers, improving solubility and pharmacokinetics.
• PEGylation Reagent: Serves as a key intermediate in the synthesis of PEGylated biologics, where the hydroxyl or carboxyl group can be activated for site-specific modification.
• Polymer Synthesis: Acts as a monomer or macromonomer for creating functionalized, biodegradable, or stimuli-responsive block copolymers and hydrogels.
• Surface Functionalization: Employed to modify the surface properties of materials (e.g., glass, metals, polymers) to introduce hydrophilic PEG brushes or specific reactive groups for further coupling.
• Diagnostic Reagent Intermediate: Used in the development of contrast agents, fluorescent probes, and other diagnostic tools requiring biocompatible spacers.
• Crosslinking Agent: Facilitates the formation of networks in hydrogel fabrication for tissue engineering and controlled release applications.

Basic Information

Product Name	Ho-Peg8-Ch2Ch2Cooh CAS NO 937188-60-8
CAS No.	937188-60-8
Molecular Formula	C21H42O12
Molecular Weight	486.55 g/mol
Synonyms	8-Aza-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid, 25-hydroxy-; HO-PEG8-COOH; α-Hydroxy-ω-carboxy octaethylene glycol; Hydroxy-PEG8-acetic acid; 2-[2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; PEG8 diol monoacetate; 8-Aza-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid; Heterobifunctional PEG8 linker
EINECS	Contact for details

Quality Control

Our Ho-Peg8-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade specifications suitable for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, providing full traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (NMR)	Conforms (486.55 g/mol)
Acid Value (Titration)	Conforms to theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.