Description

Mpeg3-Ch2Cooh CAS NO 16024-60-5 is a specialized methoxy polyethylene glycol (mPEG) carboxylic acid derivative, a key functionalized polymer intermediate. This compound matters for its ability to introduce reactive carboxyl groups onto PEG chains, enabling precise conjugation and modification of biomolecules and materials. Industries such as pharmaceuticals, bioconjugation, and advanced material science need it for creating PEGylated drugs, diagnostic agents, and functional surface coatings.

Application

• Pharmaceutical PEGylation: A crucial linker for attaching polyethylene glycol (PEG) chains to therapeutic proteins, peptides, and small molecule drugs to enhance solubility, stability, and circulation time.
• Bioconjugation Reagent: Used to functionalize antibodies, enzymes, and other biomolecules with carboxyl groups for subsequent coupling with amines via carbodiimide chemistry (e.g., EDC/NHS).
• Polymer & Material Synthesis: Serves as a macroinitiator or monomer for creating functional block copolymers, hydrogels, and smart materials with tailored properties.
• Surface Modification: Employed to graft hydrophilic, non-fouling PEG layers onto nanoparticles, medical devices, and diagnostic surfaces to improve biocompatibility.
• Diagnostic & Imaging Agent Production: Facilitates the development of contrast agents and fluorescent probes by providing a biocompatible linker between targeting moieties and imaging labels.
• Drug Delivery System Fabrication: A building block for constructing micelles, liposomes, and polymer-drug conjugates with controlled release profiles.

Basic Information

Product Name	Mpeg3-Ch2Cooh
CAS No.	16024-60-5
Molecular Formula	CnH2n+2O(n/3)+2 (n~3) *Contact for precise formula based on exact mPEG chain length*
Molecular Weight	~250-350 g/mol (for mPEG3 derivative) *Contact for exact MW*
Synonyms	mPEG3-acid; mPEG3-COOH; Methoxy(triethylene glycol) acetic acid; 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid; α-Methoxy-ω-carboxymethyltri(ethylene glycol); Triethylene glycol monomethyl ether acetic acid; PEG3 methyl ether carboxylic acid; mPEG(3) carboxylic acid
EINECS	Contact for details

Quality Control

Our Mpeg3-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and titration for acid value determination, to ensure it meets precise specifications for bioconjugation and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Acid Value (Titration)	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.