Description

Poly(Propylene Glycol)-Block-Poly(Ethylene Glycol)-Block-Poly(Propylene Glycol) Bis(2-Aminopropyl Ether) is a high-purity, amine-terminated triblock copolymer surfactant. This versatile chemical is valued for its unique amphiphilic structure, which provides excellent surface activity, biocompatibility, and tunable properties based on its block ratios. It is essential for formulators and researchers in the pharmaceutical, biomedical, and advanced materials sectors who require precise functionalization and controlled interactions in complex systems.

Application

• Pharmaceutical Excipient & Drug Delivery: As a functional polymer for modifying surfaces of nanoparticles, liposomes, and micelles to enhance drug solubility, stability, and targeted delivery.
• Biomaterial & Medical Device Coating: Used to create stealth, non-fouling surfaces on implants and diagnostic devices to reduce protein adsorption and improve biocompatibility.
• Polymer Synthesis & Modification: Acts as a macroinitiator or chain extender in the synthesis of polyurethanes, polyureas, and other segmented copolymers, introducing hydrophilic PEG segments and reactive amine sites.
• Surface Modification Agent: For grafting onto inorganic nanoparticles (e.g., silica, quantum dots) to improve dispersion in aqueous and organic media and provide reactive handles for further conjugation.
• Gene Delivery Vector Component: Incorporated into polyplex formulations to shield cationic charges, reduce cytotoxicity, and improve the efficiency of nucleic acid delivery.
• Lubricant & Functional Fluid Additive: Serves as a high-performance additive in specialty lubricants and hydraulic fluids, offering viscosity modification and surface-wetting properties.

Basic Information

Product Name	Poly(Propylene Glycol)-Block-Poly(Ethylene Glycol)-Block-Poly(Propylene Glycol) Bis(2-Aminopropyl Ether)
CAS No.	65605-36-9
Molecular Formula	Typically represented as (C3H6O)m(C2H4O)n(C3H6O)p with terminal amine groups. Exact formula varies by molecular weight.
Molecular Weight	Variable (based on m, n, p block lengths). Common grades range from 1,000 to 5,000 g/mol. Contact for details.
Synonyms	PPG-PEG-PPG Diamine; Jeffamine® ED-series (e.g., ED-2003); Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) bis(2-aminopropyl ether); α,ω-Bis(2-aminopropyl) poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol); PEG-PPG-PEG tri-block copolymer diamine; Amine-terminated Pluronic® analog; Polyoxypropylene-polyoxyethylene- polyoxypropylene diamine; Triblock copolymer diamine
EINECS	Contact for details.

Quality Control

Our Poly(Propylene Glycol)-Block-Poly(Ethylene Glycol)-Block-Poly(Propylene Glycol) Bis(2-Aminopropyl Ether) is manufactured under a strict quality management system. Each batch is characterized to ensure consistent block composition, molecular weight, and amine functionality. We provide comprehensive Certificates of Analysis (COA) detailing key specifications. Our production can adhere to cGMP guidelines for pharmaceutical applications, with documentation support available upon request.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). Store under dry, inert atmosphere (nitrogen or argon) at room temperature (15-25°C) in a cool, dry, well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (Amine Value)	As per COA (typically 0.5 - 1.5 meq/g)
Molecular Weight (GPC)	As per grade (e.g., 2000, 3000 Da ±10%)
Ethylene Oxide (EO) Content	10% - 80% (by weight, as per grade)
Water Content (KF)	≤ 0.5% w/w
Color (APHA)	≤ 100

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.