Description

H2N-Peg11-Oh CAS NO 15332-94-2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a hydroxyl group at the other. This bifunctionality is critical for creating custom linkers and spacers in bioconjugation and materials science, enabling the precise attachment of molecules while imparting beneficial PEG properties like solubility and reduced immunogenicity. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require reliable, well-defined PEGylation reagents.

Application

• Bioconjugation Linker: Used to conjugate peptides, proteins, antibodies, or other biomolecules to surfaces, nanoparticles, or other functional molecules via its amine-reactive end.
• PEGylation Reagent: Serves as a spacer arm in the PEGylation of therapeutic proteins and peptides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Diagnostic Probe Synthesis: Employed in the construction of fluorescent probes, imaging agents, and biosensors where a hydrophilic spacer is needed between the targeting moiety and the label.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinking agent or functional monomer in the synthesis of biocompatible hydrogels and polymeric materials for drug delivery and tissue engineering.
• Surface Functionalization: Used to create amine- or hydroxyl-terminated self-assembled monolayers (SAMs) on gold, silicon, or other substrates for subsequent chemical modification.
• Solid-Phase Peptide Synthesis (SPPS): Can be utilized as a soluble polymer support or as part of a cleavable linker system.
• Nanoparticle Coating: Applied to functionalize the surface of quantum dots, liposomes, or other nanoparticles to improve biocompatibility and enable further conjugation.

Basic Information

Product Name	H2N-Peg11-Oh
CAS No.	15332-94-2
Molecular Formula	C24H49NO12
Molecular Weight	543.65 g/mol
Synonyms	11-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol; Amino-PEG11-alcohol; α-Amino-ω-hydroxyundeca(ethylene glycol); O-(2-Aminoethyl)-O′-(2-hydroxyethyl)undecaethylene glycol; Amino-PEG11-OH; H2N-PEG11-OH; PEG11 diol, monoamino; Heterobifunctional PEG 11, amine and hydroxyl
EINECS	Contact for details

Quality Control

Our H2N-Peg11-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and functional group integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures material consistency suitable for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or waxy solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Group)	≥ 90% (Amino, by titration)
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	543.65 ± 5 Da
Polydispersity Index (PDI)	≤ 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.