Description

o-(2-Carboxyethyl)Polyethylene Glycol is a functionalized PEG derivative featuring a terminal carboxylic acid group, offering a versatile platform for bioconjugation and polymer modification. This compound is valued for its ability to introduce hydrophilic, non-immunogenic PEG chains onto molecules or surfaces, a process known as PEGylation, which can enhance solubility, stability, and circulation time. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity building blocks for drug delivery systems, diagnostic reagents, and functional polymers.

Application

• Pharmaceutical PEGylation: Covalent attachment to therapeutic proteins, peptides, and small molecule drugs to improve pharmacokinetic profiles and reduce immunogenicity.
• Bioconjugation & Crosslinking: Used as a heterobifunctional linker for coupling biomolecules (e.g., antibodies, enzymes) to other entities via its reactive carboxyl group.
• Polymer & Surface Modification: Grafting onto nanoparticles, medical devices, or chromatographic media to impart stealth properties, enhance biocompatibility, and reduce non-specific binding.
• Hydrogel Synthesis: Serving as a water-soluble macromonomer or crosslinker in the creation of hydrogels for biomedical applications like tissue engineering and controlled drug release.
• Diagnostic Reagent Preparation: Conjugation with dyes, probes, or haptens to create reagents for immunoassays and biosensors.
• Cosmetic & Personal Care Formulations: Acting as a functional ingredient to modify rheology, provide moisturization, or stabilize active ingredients in advanced formulations.

Basic Information

Product Name	o-(2-Carboxyethyl)Polyethylene Glycol
CAS No.	117786-94-4
Molecular Formula	Contact for details (PEG derivative, variable chain length)
Molecular Weight	Contact for details (dependent on PEG chain length, typically 500 - 5000 Da)
Synonyms	Carboxyethyl PEG; PEG-Carboxylic Acid; α-(2-Carboxyethyl)-ω-hydroxy-poly(oxy-1,2-ethanediyl); Poly(ethylene glycol) 2-carboxyethyl ether; mPEG-CM; Carboxymethyl PEG; PEG-propionic acid; HO-PEG-COOH
EINECS	Contact for details

Quality Control

Our o-(2-Carboxyethyl)Polyethylene Glycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, acid value, polydispersity index (PDI), and residual solvent content. We support cGMP manufacturing for pharmaceutical applications and can tailor specifications to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and prevent hydrolysis of the active carboxyl group.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Acid Value)	≥95% (or as per customer grade)
Average Molecular Weight (GPC)	As per ordered grade (e.g., 500, 1000, 2000, 5000 Da)
Polydispersity Index (PDI)	≤1.05 - 1.10
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.