Description

4-Boc-1-[(3-Bromobenzene)Sulfonyl]Piperazine is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound is specifically designed for the efficient construction of complex molecules, offering a protected piperazine core with orthogonal reactivity for further functionalization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially those containing a piperazine sulfonamide pharmacophore.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for the discovery of new therapeutic agents.
• CNS Drug Development: Serves as a key precursor in the synthesis of compounds targeting neurological receptors and enzymes.
• Chemical Biology Probes: Employed in the creation of tool compounds and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules under cGMP conditions.
• Academic Research: Used in university and institutional labs for methodological development in synthetic organic chemistry.

Basic Information

Item	Detail
Product Name	4-Boc-1-[(3-Bromobenzene)Sulfonyl]Piperazine
CAS No.	937014-80-7
Molecular Formula	C15H21BrN2O4S
Molecular Weight	405.31 g/mol
Synonyms	1-Boc-4-(3-Bromobenzenesulfonyl)piperazine; tert-Butyl 4-(3-bromobenzenesulfonyl)piperazine-1-carboxylate; 4-(3-Bromophenylsulfonyl)-1-(tert-butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(3-bromobenzenesulfonyl)piperazine; 4-Boc-1-(3-bromophenylsulfonyl)piperazine; N-Boc-4-(3-bromobenzenesulfonyl)piperazine; Piperazine, 1-[(3-bromophenyl)sulfonyl]-, 1-(1,1-dimethylethyl) ester; 937014-80-7
EINECS	Contact for details

Quality Control

Our 4-Boc-1-[(3-Bromobenzene)Sulfonyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and residual solvents. Our quality commitment supports applications in regulated environments, including pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.