Description

(4R,5R)-5-Amino-1-Benzyl-4-(2,4,5-Trifluorophenyl)Piperidin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and trifluorophenyl moiety. This compound is of critical importance for the synthesis of novel, targeted therapeutic agents, particularly in the development of enzyme inhibitors and receptor modulators. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new chemical entities, especially within oncology and central nervous system (CNS) drug pipelines.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Protease Inhibitor Development: Used in the research and synthesis of compounds targeting specific proteases, such as DPP-4, for metabolic disease treatments.
• Kinase Inhibitor Scaffold: Serves as a core structural element for creating novel kinase inhibitors with potential applications in oncology.
• Neurological Drug Research: Employed in the development of ligands and modulators for neurological targets.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and cGMP manufacturing for clinical trial material supply.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs in academic labs and CROs (Contract Research Organizations).

Basic Information

Product Name	(4R,5R)-5-Amino-1-Benzyl-4-(2,4,5-Trifluorophenyl)Piperidin-2-One
CAS No.	936482-13-2
Molecular Formula	C18H18F3N3O
Molecular Weight	349.35 g/mol
Synonyms	5-Amino-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-2-one; (4R,5R)-5-Amino-1-benzyl-4-(2,4,5-trifluorophenyl)-2-piperidinone; 1-Benzyl-5-amino-4-(2,4,5-trifluorophenyl)piperidin-2-one; (4R,5R)-rel-5-Amino-1-benzyl-4-(2,4,5-trifluorophenyl)-2-piperidinone; 936482-13-2; ABT-341 intermediate; DPP-4 inhibitor intermediate; Saxagliptin related compound
EINECS	Contact for details

Quality Control

Our (4R,5R)-5-Amino-1-Benzyl-4-(2,4,5-Trifluorophenyl)Piperidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.