Description

(S)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride is a high-purity, chiral piperazine derivative of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block (intermediate) for the synthesis of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in drug discovery and process chemistry. The specific stereochemistry and functional groups make it a valuable scaffold for creating targeted molecules with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Development & Scale-Up: Serves as a reference standard and starting material for developing robust, GMP-compliant manufacturing routes for Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Custom Synthesis: A foundational molecule for the custom synthesis of more complex, proprietary compounds for client-specific research programs.

Basic Information

Product Name	(S)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride
CAS No.	936233-08-8
Molecular Formula	C19H27Cl2N3O4S
Molecular Weight	464.41 g/mol
Synonyms	(S)-3-Methyl-1-[(5-isoquinolinyl)sulfonyl]-4-piperazinecarboxylic acid 1,1-dimethylethyl ester dihydrochloride; tert-Butyl (S)-3-methyl-4-(isoquinoline-5-sulfonyl)piperazine-1-carboxylate dihydrochloride; (S)-3-Methyl-4-(5-isoquinolinesulfonyl)piperazine-1-carboxylic acid tert-butyl ester dihydrochloride; (S)-4-(Isoquinoline-5-sulfonyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester dihydrochloride; (S)-t-Butyl 3-methyl-4-(isoquinoline-5-sulfonyl)piperazine-1-carboxylate dihydrochloride; 936233-08-8; BOC-(S)-3-Methylpiperazine-5-isoquinolinesulfonamide dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.