Description

(S) 5-(3-Isopropyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride is a high-purity, chiral chemical building block and pharmaceutical intermediate. This compound matters for its critical role in the research and development of novel therapeutic agents, particularly in medicinal chemistry programs targeting specific biological pathways. Pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers need it for synthesizing potential drug candidates, especially in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Tool Compound: Serves as a selective ligand or inhibitor in pharmacological assays to study enzyme or receptor function.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale under current Good Manufacturing Practices (cGMP).
• Academic Research: Utilized in university and institutional labs for organic synthesis methodology development and chemical biology studies.
• Custom Synthesis & Contract Manufacturing: A starting material for the bespoke production of complex molecules for client-specific projects.

Basic Information

Product Name	(S) 5-(3-Isopropyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride
CAS No.	936233-02-2
Molecular Formula	C₁₆H₂₄Cl₂N₄O₂S
Molecular Weight	407.36 g/mol
Synonyms	(S)-5-(3-Isopropylpiperazine-1-sulfonyl)isoquinoline dihydrochloride; (S)-5-[(3-Isopropyl-1-piperazinyl)sulfonyl]isoquinoline dihydrochloride; 5-[(3-Isopropyl-1-piperazinyl)sulfonyl]isoquinoline, (S)-, dihydrochloride; UNII-8J7I6V6V8R; 8J7I6V6V8R; (S)-5-(3-Isopropylpiperazine-1-sulfonyl)isoquinoline 2HCl; (S)-5-(3-Isopropyl-piperazine-1-sulfonyl)-isoquinoline dihydrochloride
EINECS	Contact for details

Quality Control

Our (S) 5-(3-Isopropyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.