Description

(S)-5-(3-Isobutyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride is a high-purity, chiral organic compound primarily utilized as a sophisticated building block in pharmaceutical research and development. Its value lies in its specific stereochemistry and functional groups, which make it a critical intermediate for synthesizing novel active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular pathways. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development and optimization of scalable synthetic routes for potential APIs.
• Reference Standard: Employed as an analytical standard for method development, quality control, and regulatory submissions in pharmaceutical manufacturing.
• Biochemical Tool Compound: Used in vitro and in vivo to study specific biological pathways and enzyme interactions relevant to disease mechanisms.
• Custom Synthesis Starting Material: Provides a versatile core structure for the custom synthesis of more complex, target-specific molecules for client R&D projects.

Basic Information

Product Name	(S)-5-(3-Isobutyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride
CAS No.	936233-01-1
Molecular Formula	C17H26Cl2N4O2S
Molecular Weight	421.38 g/mol
Synonyms	(S)-5-(3-Isobutylpiperazine-1-sulfonyl)isoquinoline dihydrochloride; (S)-5-[(3-Isobutyl-1-piperazinyl)sulfonyl]isoquinoline Dihydrochloride; 936233-01-1; UNII-9P6K8CJ0QN; 9P6K8CJ0QN; (S)-5-(3-Isobutyl-piperazine-1-sulfonyl)-isoquinoline 2HCl; (S)-5-(3-Isobutylpiperazine-1-sulfonyl)isoquinoline hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our (S)-5-(3-Isobutyl-Piperazine-1-Sulfonyl)-Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable and reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.