Description

(2S)-2-Hydroxybutanedioic Acid Compd. With (Alphar)-N,α-Dimethyl-3,5-Bis(Trifluoromethyl)Benzenemethanamine is a high-purity, non-racemic chiral compound designed for advanced chemical synthesis. This material is a critical intermediate for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of potent neurokinin-1 (NK1) receptor antagonists. It is essential for pharmaceutical R&D and manufacturing organizations requiring a reliable source of a complex, enantiomerically pure building block with trifluoromethyl functionalities.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of Aprepitant, Fosaprepitant, and other NK1 receptor antagonist APIs.
• Asymmetric Synthesis: Used in chiral pool synthesis and resolution processes to introduce stereochemical complexity.
• Process Chemistry R&D: Serves as a reference standard and starting material for route scouting and optimization in drug development.
• Contract Manufacturing (CMO): Supplied to CMOs for the commercial-scale production of branded and generic pharmaceuticals.
• High-Purity Chemical Synthesis: Employed in the preparation of other complex organic molecules requiring the (2S)-2-hydroxybutanedioic acid moiety.

Basic Information

Product Name	(2S)-2-Hydroxybutanedioic Acid Compd. With (Alphar)-N,α-Dimethyl-3,5-Bis(Trifluoromethyl)Benzenemethanamine
CAS No.	935534-56-8
Molecular Formula	C17H19F6NO5
Molecular Weight	431.33 g/mol
Synonyms	(2S)-Malic Acid Compd. with (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine; Aprepitant Intermediate; Fosaprepitant Intermediate; L-Malic Acid Salt of Aprepitant Amine; NK1 Receptor Antagonist Intermediate; (αR)-N,α-Dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine (2S)-2-hydroxybutanedioate; EMEND® Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical methods including HPLC for chiral purity and assay, residual solvent analysis, and identification tests. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with client specifications or our standard pharmacopeial-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.