Description

Calcipotriol (Calcipotriene) β-Isomer CAS NO 934338-44-0 is a specific stereoisomer of the synthetic vitamin D3 analog, calcipotriol, which is a key active pharmaceutical ingredient (API) and a critical reference standard. This compound is essential for research and development in dermatology, particularly for the treatment of psoriasis, due to its role in regulating skin cell growth and differentiation. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories focused on developing and quality-controlling topical formulations.

Application

• Pharmaceutical Active Ingredient (API): Serves as the primary active component in topical creams, ointments, and solutions for the treatment of plaque psoriasis.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Biochemical Research: Employed in studies investigating the mechanism of action of vitamin D analogs on keratinocyte proliferation and immune modulation.
• Formulation Development: Critical for R&D scientists developing new dermatological drug delivery systems and combination therapies.
• Impurity Profiling: Used to identify, quantify, and control related substances and stereoisomeric impurities in calcipotriol bulk drug substances.
• Stability Studies: Acts as a benchmark in forced degradation and shelf-life studies for calcipotriol-based pharmaceutical products.

Basic Information

Product Name	Calcipotriol (Calcipotriene) β-Isomer
CAS No.	934338-44-0
Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.61 g/mol
Synonyms	Calcipotriene β-Isomer; (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol; MC 903 β-Isomer; 1α,24(S)-Dihydroxy-22-ene-26,27-cyclopropyl-19-nor-vitamin D3; Daivonex Impurity; Psorcutan Impurity; Dovonex Impurity
EINECS	Contact for details

Quality Control

Our Calcipotriol β-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and specific rotation. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.