Description

(R)-4-Isopropyl-2-(Quinolin-2-Yl)-4,5-Dihydrooxazole is a high-purity chiral oxazoline derivative, a crucial building block in asymmetric synthesis and pharmaceutical research. Its value lies in its role as a versatile ligand precursor and organocatalyst, enabling the production of enantiomerically pure compounds with high selectivity. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients and optimize synthetic routes.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral ligands used in transition metal-catalyzed reactions such as hydrogenation, hydrosilylation, and cross-coupling.
• Pharmaceutical Intermediates: A key chiral synthon in the research and development of enantiopure drug candidates, particularly in central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Organocatalysis: Functions as an organocatalyst or catalyst modifier in various carbon-carbon and carbon-heteroatom bond-forming reactions.
• Material Science Research: Investigated for the synthesis of chiral polymers and advanced materials with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process chemistry laboratories.

Basic Information

Product Name	(R)-4-Isopropyl-2-(Quinolin-2-Yl)-4,5-Dihydrooxazole
CAS No.	933992-49-5
Molecular Formula	C₁₅H₁₆N₂O
Molecular Weight	240.30 g/mol
Synonyms	(R)-4-Isopropyl-2-(quinolin-2-yl)-4,5-dihydrooxazole; (R)-2-(2-Quinolyl)-4-isopropyl-4,5-dihydrooxazole; (R)-4-Isopropyl-2-(2-quinolyl)-2-oxazoline; (R)-4-(Propan-2-yl)-2-(quinolin-2-yl)-4,5-dihydro-1,3-oxazole; (R)-Quinox; (R)-IPQO; (R)-Isoquinoline-oxazoline ligand precursor
EINECS	Contact for details

Quality Control

Our (R)-4-Isopropyl-2-(Quinolin-2-Yl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.