Description

Amino-Peg12-Alcohol CAS NO 933789-97-0 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a hydroxyl group at the other, separated by a 12-unit PEG spacer. This bifunctionality is critical for creating stable, hydrophilic linkers in bioconjugation and pharmaceutical development, improving the solubility and pharmacokinetic profiles of therapeutic agents. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable PEGylation reagents.

Application

• Bioconjugation and PEGylation: Used to conjugate peptides, proteins, antibodies, or small molecule drugs, enhancing their solubility, stability, and circulation time in vivo.
• Pharmaceutical Linker: Serves as a versatile spacer in antibody-drug conjugates (ADCs) and prodrugs, connecting payloads to targeting moieties.
• Surface Modification: Functionalizes nanoparticles, quantum dots, and diagnostic beads to improve biocompatibility and reduce non-specific binding.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinking agent or monomer for creating hydrophilic, biocompatible polymer networks and scaffolds.
• Diagnostic Reagent Preparation: Utilized in the development of fluorescent probes, biosensors, and assay components where a hydrophilic spacer is required.
• Solid-Phase Peptide Synthesis (SPPS): Can be employed as a soluble polymer support or as part of a cleavable linker system.

Basic Information

Product Name	Amino-Peg12-Alcohol
CAS No.	933789-97-0
Molecular Formula	C26H55NO13
Molecular Weight	589.72 g/mol
Synonyms	12-Amino-4,7,10-trioxadodecan-1-ol; 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxa-38-azaoctatriacontan-38-ol; Amino-PEG12-OH; NH2-PEG12-OH; α-Amino-ω-hydroxy-dodecaethylene glycol; 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontan-1-amine; H2N-PEG12-CH2CH2OH
EINECS	Contact for details

Quality Control

Our Amino-Peg12-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (by titration)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.