Description

Benzyl (3R)-3-(Hydroxymethyl)Piperazine-1-Carboxylate is a high-purity chiral piperazine derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and infectious diseases. This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially in neurological and anti-infective therapeutic areas.
• API Development: Serves as a foundational building block in the research and scale-up production of Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce the (R)-configured hydroxymethyl piperazine moiety into target molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	Benzyl (3R)-3-(Hydroxymethyl)Piperazine-1-Carboxylate
CAS No.	930837-03-9
Molecular Formula	C13H18N2O3
Molecular Weight	250.30 g/mol
Synonyms	1-Carbobenzyloxy-(3R)-3-hydroxymethylpiperazine; (R)-1-Cbz-3-(hydroxymethyl)piperazine; Benzyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate; (R)-1-N-Cbz-3-piperazinemethanol; (3R)-3-(Hydroxymethyl)-1-(phenylmethoxy)carbonylpiperazine; 1-[(Benzyloxy)carbonyl]-(3R)-3-piperazinemethanol; (R)-3-Hydroxymethyl-1-Cbz-piperazine; Cbz-(R)-3-hydroxymethylpiperazine
EINECS	Contact for details

Quality Control

Our Benzyl (3R)-3-(Hydroxymethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.