Description

(S)-Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate is a high-purity chiral piperazine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with defined stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) where the (S)-configured piperazine scaffold is required.
• Peptidomimetics & PROTACs: Serves as a core structural component in the design of peptidomimetic compounds and Proteolysis Targeting Chimeras (PROTACs).
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organometallic complexes.
• Chemical Biology Research: Utilized as a molecular probe or building block in medicinal chemistry and chemical biology studies to explore structure-activity relationships (SAR).
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom fine chemicals for clients.

Basic Information

Product Name	(S)-Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate
CAS No.	930837-02-8
Molecular Formula	C13H18N2O3
Molecular Weight	250.29 g/mol
Synonyms	(S)-1-Benzyloxycarbonyl-3-hydroxymethylpiperazine; (S)-1-CBZ-3-(Hydroxymethyl)piperazine; (S)-3-(Hydroxymethyl)-1-[(phenylmethoxy)carbonyl]piperazine; (S)-N-CBZ-3-Piperazinemethanol; (S)-Benzyl 3-(Hydroxymethyl)piperazine-1-carboxylate; (S)-1-N-CBZ-3-Hydroxymethylpiperazine; (S)-Piperazine-1-carboxylic acid benzyl ester 3-methanol; (S)-3-Hydroxymethyl-1-CBZ-piperazine
EINECS	Contact for details

Quality Control

Our (S)-Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.