Description

(9Ar)-Hexahydropyrazino-[2,1-C][1,4]Oxazin-4(3H)-One is a sophisticated heterocyclic organic compound, specifically a fused bicyclic lactam, that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique bridged structure makes it a valuable building block for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). This high-purity compound is essential for research and production teams in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for complex synthesis, process development, and scale-up activities. CAS number 930783-26-9 uniquely identifies this specific stereoisomer.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Organic Synthesis Building Block: Used in the construction of complex nitrogen- and oxygen-containing heterocycles due to its fused pyrazino-oxazinone core.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of target molecules requiring this specific stereochemistry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for generating focused libraries in structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in enantioselective synthesis pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific synthesis projects.

Basic Information

Product Name	(9Ar)-Hexahydropyrazino-[2,1-C][1,4]Oxazin-4(3H)-One
CAS No.	930783-26-9
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	(9aR)-Octahydropyrazino[2,1-c][1,4]oxazine-4-one; (9aR)-Hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-4(6H)-one; (R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one; (9aR)-1,2,3,6,7,8,9,9a-Octahydro-4H-pyrazino[2,1-c][1,4]oxazin-4-one; (R)-Fused Bicyclic Lactam Intermediate; AR-Hexahydropyrazino-oxazinone
EINECS	Contact for details

Quality Control

Our (9Ar)-Hexahydropyrazino-[2,1-C][1,4]Oxazin-4(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and standard pharmacopeial methods for identity and assay. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, chiral purity, and impurity profiles to ensure it meets the exacting standards required for pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.