Description

(3R)-3-(Hydroxymethyl)-1-Piperazinecarboxylic Acid Phenylmethyl Ester Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, ensuring the efficacy and safety of final drug products. This intermediate is essential for research and development chemists and manufacturers in the global pharmaceutical and biotechnology sectors, particularly those focused on novel active pharmaceutical ingredients (APIs) and fine chemical production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• API Development: Used in research-scale and process chemistry for constructing the core structure of new chemical entities (NCEs) and active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block to introduce stereogenic centers in medicinal chemistry programs.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and synthesis of peptide analogs and mimetics for drug discovery.
• Chemical Biology Probes: Utilized in the development of tool compounds and molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	(3R)-3-(Hydroxymethyl)-1-Piperazinecarboxylic Acid Phenylmethyl Ester Hydrochloride
CAS No.	930782-91-5
Molecular Formula	C13H19ClN2O3
Molecular Weight	286.76 g/mol
Synonyms	(R)-3-(Hydroxymethyl)-1-Cbz-piperazine hydrochloride; (R)-1-Cbz-3-(hydroxymethyl)piperazine hydrochloride; Benzyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate hydrochloride; (R)-1-(Benzyloxycarbonyl)-3-(hydroxymethyl)piperazine hydrochloride; (R)-1-N-Cbz-3-piperazinemethanol hydrochloride; (3R)-1-[(Benzyloxy)carbonyl]-3-(hydroxymethyl)piperazine hydrochloride; (R)-3-Hydroxymethyl-1-CBZ-piperazine HCl; (R)-1-CBZ-3-piperazinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (3R)-3-(Hydroxymethyl)-1-Piperazinecarboxylic Acid Phenylmethyl Ester Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, and the material is suitable for use in pharmaceutical research and development. Comprehensive analytical testing is performed, including chiral purity verification. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.