Description

(R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine CAS NO 930782-89-1 is a high-purity, chiral piperazine derivative, a crucial building block in modern pharmaceutical synthesis. This compound matters because it provides a protected, stereochemically defined scaffold essential for constructing complex active pharmaceutical ingredients (APIs) with high enantiomeric purity. Pharmaceutical R&D and process chemistry teams need it for the development of novel therapeutics, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for protease inhibitors and receptor antagonists.
• API Development: Used in research and process development for Active Pharmaceutical Ingredients (APIs) requiring a stereochemically pure piperazine core.
• Peptidomimetics: Serves as a constrained scaffold in the design and synthesis of peptide mimics for enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of tool compounds and molecular probes for studying biological pathways and target validation.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine
CAS No.	930782-89-1
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	(R)-1-(Benzyloxycarbonyl)-4-(tert-butoxycarbonyl)-2-(hydroxymethyl)piperazine; (R)-1-Cbz-4-Boc-2-hydroxymethylpiperazine; (R)-N-Cbz-N'-Boc-2-hydroxymethylpiperazine; (R)-2-(Hydroxymethyl)-1,4-bis(oxycarbonyl)piperazine (Boc/Cbz protected); (R)-1,4-Bis(oxycarbonyl)-2-piperazinemethanol; tert-Butyl (R)-4-[(benzyloxy)carbonyl]-2-(hydroxymethyl)piperazine-1-carboxylate; (R)-4-Boc-1-Cbz-2-piperazinemethanol
EINECS	Contact for details

Quality Control

Our (R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for advanced pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.