Description

(S)-4-n-Cbz-2-Hydroxymethyl-Piperazine -Hcl is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs), particularly in the creation of complex molecules with specific stereochemical requirements. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of targeted therapeutics, including kinase inhibitors and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for oncology and central nervous system (CNS) diseases.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing peptide analogs and mimetics to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• API Process Development: Employed in the scale-up and optimization of synthetic routes for complex target molecules during clinical and commercial manufacturing.
• Chemical Biology Probes: Used in the construction of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	(S)-4-n-Cbz-2-Hydroxymethyl-Piperazine -Hcl
CAS No.	930782-84-6
Molecular Formula	C14H21N3O3 • HCl
Molecular Weight	315.79 g/mol (Free base: 279.33 g/mol)
Synonyms	(S)-1-Cbz-4-Aminopiperidine-2-methanol Hydrochloride; (S)-1-[(Benzyloxy)carbonyl]-4-amino-2-piperidinemethanol Hydrochloride; (S)-N-Cbz-4-Amino-2-piperidinemethanol HCl; (S)-4-(Benzyloxycarbonylamino)-2-(hydroxymethyl)piperazine Hydrochloride; (S)-4-(Cbz-amino)-2-hydroxymethylpiperazine HCl; (S)-4-Carbobenzyloxyamino-2-hydroxymethylpiperazine Hydrochloride; (2S)-1-[(Benzyloxy)carbonyl]-4-amino-2-piperidinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-n-Cbz-2-Hydroxymethyl-Piperazine -Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.