Description

4-(4-Cyano-2-Fluorophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional piperazine derivative and a key synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring a cyano group, a fluorine atom, and a Boc-protected piperazine ring, makes it a versatile building block for constructing complex pharmacologically active molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, kinase inhibitors, and other receptor-targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine and cyano substituents for enhanced biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a precursor for designing molecular probes, enzyme inhibitors, and other tools for studying biological pathways and drug discovery.
• Material Science: Potential use as a monomer or precursor in the synthesis of specialty polymers and advanced organic materials with specific electronic or structural properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	4-(4-Cyano-2-Fluorophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	929884-77-5
Molecular Formula	C16H20FN3O2
Molecular Weight	305.35 g/mol
Synonyms	1-Boc-4-(4-cyano-2-fluorophenyl)piperazine; tert-Butyl 4-(4-cyano-2-fluorophenyl)piperazine-1-carboxylate; 4-(4-Cyano-2-fluorophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(4-cyano-2-fluorophenyl)piperazine; N-Boc-4-(4-cyano-2-fluorophenyl)piperazine; 929884-77-5; 4-Cyano-2-fluorophenyl piperazine Boc ester
EINECS	Contact for details

Quality Control

Our production of 4-(4-Cyano-2-Fluorophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR and IR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications. We support development and commercial projects with material suitable for research use or produced under a quality system aligned with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.