Description

(R)-1-Boc-3-Isobutylpiperazine is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this Boc-protected intermediate for its defined stereochemistry and functional group compatibility, enabling precise and efficient synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where specific chirality impacts biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: Incorporated into the backbone of peptide analogs to modulate stability, bioavailability, and receptor binding.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental component for custom synthesis projects requiring high-fidelity chiral piperazine chemistry.

Basic Information

Product Name	(R)-1-Boc-3-Isobutylpiperazine
CAS No.	928025-61-0
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-(2-methylpropyl)piperazine; (R)-3-Isobutyl-1-Boc-piperazine; (R)-N-Boc-3-isobutylpiperazine; tert-Butyl (R)-3-isobutylpiperazine-1-carboxylate; (R)-1-Boc-3-(2-methylpropyl)piperazine; (R)-1-N-Boc-3-isobutylpiperazine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-(2-methylpropyl)piperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Isobutylpiperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.