Description

tert-Butyl 4-(2-Chloro-4-Nitrobenzoyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine and nitrobenzoyl functional groups. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and R&D laboratories focused on developing new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new pharmacophores with enhanced efficacy and selectivity.
• API Synthesis: Serves as a precursor in multi-step synthetic routes for the production of potential Active Pharmaceutical Ingredients (APIs) containing piperazine and aryl ketone motifs.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and protein-ligand interactions in academic and industrial research settings.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services for clinical trial materials.

Basic Information

Product Name	tert-Butyl 4-(2-Chloro-4-Nitrobenzoyl)Piperazine-1-Carboxylate
CAS No.	927608-11-5
Molecular Formula	C16H20ClN3O5
Molecular Weight	369.80 g/mol
Synonyms	1-Boc-4-(2-Chloro-4-nitrobenzoyl)piperazine; tert-Butyl 4-[(2-chloro-4-nitrophenyl)carbonyl]piperazine-1-carboxylate; 4-(2-Chloro-4-nitrobenzoyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-chloro-4-nitrobenzoyl)piperazine; 2-Chloro-4-nitro-1-[4-(tert-butoxycarbonyl)piperazin-1-yl]methanone; Boc-4-(2-Chloro-4-Nitrobenzoyl)Piperazine; Piperazine, 1-[(2-chloro-4-nitrophenyl)carbonyl]-4-(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Chloro-4-Nitrobenzoyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark place to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.