Description

1-(4-Chloro-2-Fluorobenzoyl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzoylpiperazine structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical manufacturers, agrochemical developers, and dedicated contract research organizations (CROs) require this precise intermediate to ensure the efficacy and purity of their final drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its halogenated aromatic structure.
• Chemical Synthesis: Serves as a versatile precursor for creating complex piperazine-derived compounds in medicinal chemistry.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and process development.
• Academic & Institutional Research: Utilized in university and institutional labs for pharmacological studies and new molecular entity (NME) discovery.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biological target identification and validation.

Basic Information

Product Name	1-(4-Chloro-2-Fluorobenzoyl)Piperazine
CAS No.	926227-66-9
Molecular Formula	C11H12ClFN2O
Molecular Weight	242.68 g/mol
Synonyms	4-Chloro-2-fluoro-1-(piperazine-1-carbonyl)benzene; 1-(4-Chloro-2-fluorobenzoyl)piperazine; 4-Chloro-2-fluorobenzoylpiperazine; N-(4-Chloro-2-fluorobenzoyl)piperazine; 926227-66-9; 4-Chloro-2-fluoro-N-(piperazin-1-yl)benzamide; 1-Piperazinecarboxamide, N-(4-chloro-2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluorobenzoyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.