Description

4-[4-(Aminomethyl)Benzoyl]Piperazin-2-One CAS NO 926211-94-1 is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperazinone and benzoyl structural motifs. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new chemical entities and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Protease Inhibitor Research: Serves as a core scaffold or side-chain component in the development of novel protease inhibitors due to its amide and amine functionalities.
• Kinase Inhibitor Development: Utilized in medicinal chemistry programs for constructing kinase inhibitor libraries, leveraging its potential for hydrogen bonding and molecular recognition.
• Peptidomimetic Chemistry: Acts as a constrained, non-natural amino acid analog in the design of peptidomimetics to enhance metabolic stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Chemical Biology & Biochemical Tool Development: Used to create probes and ligands for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	4-[4-(Aminomethyl)Benzoyl]Piperazin-2-One
CAS No.	926211-94-1
Molecular Formula	C13H17N3O2
Molecular Weight	247.29 g/mol
Synonyms	4-(4-(Aminomethyl)benzoyl)piperazin-2-one; 1-[4-(Aminomethyl)benzoyl]piperazin-2-one; 2-Piperazinone, 4-[4-(aminomethyl)benzoyl]-; 4-(4-Aminomethyl-benzoyl)-piperazin-2-one; (4-(2-Oxopiperazin-1-yl)(phenyl)methyl)phenylmethanamine; 926211-94-1; 4-(4-(Aminomethyl)benzoyl)-2-piperazinone
EINECS	Contact for details

Quality Control

Our 4-[4-(Aminomethyl)Benzoyl]Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development with custom purity grades and can supply material suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.