Description

3-Oxo-Piperazine-2-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex pharmacophores, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D and fine chemical manufacturers need it for creating protease inhibitors, enzyme modulators, and other bioactive molecules with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel protease inhibitors and other small-molecule drug candidates.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics to enhance metabolic stability and bioavailability of peptide-based therapeutics.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors and activity-based probes to study biological pathways.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to introduce the piperazine-2-carboxylic acid motif into target molecules.
• Agrochemical Development: Potential intermediate in the research and synthesis of new generation herbicides or fungicides with specific modes of action.
• Material Science: Can be investigated as a monomer or cross-linker for synthesizing novel polymers with specific functional properties.

Basic Information

Product Name	3-Oxo-Piperazine-2-Carboxylic Acid
CAS No.	925890-01-3
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	2-Carboxy-3-oxopiperazine; 3-Oxo-2-piperazinecarboxylic Acid; 2-Piperazinecarboxylic acid, 3-oxo-; (S)-3-Oxopiperazine-2-carboxylic acid (for enantiopure forms); 3-Ketopiperazine-2-carboxylic Acid; 2-Carboxy-3-ketopiperazine; NSC 760443; AKOS005251169
EINECS	Contact for details

Quality Control

Our 3-Oxo-Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment where applicable, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing specific batch results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.