Description

6-Chloro-5-Iodopyrazin-2-Amine is a high-purity halogenated pyrazine derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents on the pyrazine ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, leveraging the pyrazine core for biological activity.
• Material Science Research: Serves as a building block for creating novel heterocyclic compounds used in organic electronic materials and ligands for catalysis.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of the molecule.
• Nucleophilic Aromatic Substitution: The chloro substituent is reactive towards nucleophiles, allowing for further functionalization of the pyrazine ring system.
• Chemical Library Production: Employed in high-throughput and combinatorial chemistry for generating diverse screening libraries in drug discovery.

Basic Information

Product Name	6-Chloro-5-Iodopyrazin-2-Amine
CAS No.	925678-00-8
Molecular Formula	C4H3ClIN3
Molecular Weight	255.44 g/mol
Synonyms	2-Amino-6-chloro-5-iodopyrazine; 5-Iodo-6-chloropyrazin-2-amine; 6-Chloro-5-iodo-2-pyrazinamine; 6-Chloro-5-iodopyrazine-2-amine; 925678-00-8; 2-Pyrazinamine, 6-chloro-5-iodo-
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-5-Iodopyrazin-2-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard grade typically meets a purity specification of ≥95% (HPLC), with custom purities available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The compound may be light-sensitive and should be handled under an inert atmosphere for prolonged manipulations.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.