Description

Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate is a high-value, protected piperazine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its structure, featuring both cyano and tert-butyloxycarbonyl (Boc) protecting groups, makes it an essential building block for constructing complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperazine-based drug candidates, including potential antivirals, CNS agents, and kinase inhibitors.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with piperazine cores.
• Chemical Biology & Proteomics: Used in the preparation of specialized linkers, probes, and molecular scaffolds for studying biological systems.
• Peptidomimetics & Macrocycle Synthesis: Enables the introduction of constrained piperazine units into peptide analogs and cyclic compounds to modulate bioavailability and activity.
• Material Science: Intermediate for creating functional polymers and ligands with specific coordination properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical producers for multi-step synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate
CAS No.	924964-23-8
Molecular Formula	C15H25N3O4
Molecular Weight	311.38 g/mol
Synonyms	1,4-Di-tert-butyl 2-cyano-1,4-piperazinedicarboxylate; 2-Cyanopiperazine-1,4-dicarboxylic acid di-tert-butyl ester; 1,4-Bis(tert-butoxycarbonyl)-2-cyanopiperazine; 2-Cyano-1,4-piperazinedicarboxylic Acid Di-tert-butyl Ester; Di-Boc-2-cyanopiperazine; Boc-Pip(CN)-Boc
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.