Description

1-Cbz-(2R)-Methylpiperazine is a high-purity, chiral piperazine derivative protected with a carboxybenzyl (Cbz) group. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly active pharmaceutical ingredients (APIs). It is essential for research and development chemists and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• API Synthesis: Used as a building block for constructing complex molecular architectures in the production of Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for catalysts or ligands in asymmetric transformations.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetics: Incorporated into the design and synthesis of peptide analogs and mimetics due to its piperazine backbone.
• Fine Chemical Production: Serves as a specialized intermediate for high-value, low-volume fine chemicals and custom synthesis projects.

Basic Information

Product Name	1-Cbz-(2R)-Methylpiperazine
CAS No.	923565-99-5
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	(R)-1-((Benzyloxy)carbonyl)-2-methylpiperazine; (R)-1-Cbz-2-Methylpiperazine; (2R)-1-[(Benzyloxy)carbonyl]-2-methylpiperazine; 1-[(Benzyloxy)carbonyl]-(2R)-methylpiperazine; (R)-2-Methyl-1-(phenylmethoxy)carbonylpiperazine; N-Cbz-(R)-2-Methylpiperazine; (R)-N-Carbobenzoxy-2-methylpiperazine; 923565-99-5
EINECS	Contact for details

Quality Control

Our 1-Cbz-(2R)-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.