Description

n-[2,4-Difluoro-3-[[5-(3-Pyridinyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl]Carbonyl]Phenyl]-2-Propanesulfonamide is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemistry programs, particularly in the discovery and synthesis of novel kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable supply of complex heterocyclic building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted small-molecule therapeutics, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Biochemical Research: Serves as a reference standard or probe compound in enzymatic and cellular assays.
• Contract Development and Manufacturing (CDMO): Supplied for custom synthesis and scale-up projects under cGMP or non-GMP conditions.
• Academic Research: Utilized in university and institutional labs for chemical biology and drug discovery projects.

Basic Information

Product Name	n-[2,4-Difluoro-3-[[5-(3-Pyridinyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl]Carbonyl]Phenyl]-2-Propanesulfonamide
CAS No.	918505-61-0
Molecular Formula	C22H16F2N4O3S
Molecular Weight	454.45 g/mol
Synonyms	2-Propanesulfonamide, N-[2,4-difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-; 918505-61-0; N-[2,4-Difluoro-3-({5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)phenyl]propane-2-sulfonamide; 3-Pyridinepropanamide derivative; Difluorophenyl pyrrolopyridine sulfonamide; Kinase inhibitor intermediate; Heterocyclic sulfonamide building block
EINECS	Contact for details

Quality Control

Our n-[2,4-Difluoro-3-[[5-(3-Pyridinyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl]Carbonyl]Phenyl]-2-Propanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.