Description

tert-Butyl 4-Amino-4-(4-Bromophenyl)Piperidine-1-Carboxylate is a high-value, protected piperidine derivative featuring both a primary amine and a bromoaryl functional group, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex pharmacologically active molecules, particularly in medicinal chemistry and drug discovery programs. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity intermediates for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial scaffold in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets, kinase inhibitors, and receptor modulators.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization phases to explore structure-activity relationships (SAR) due to its modifiable amine and aryl bromide sites.
• Agrochemical Synthesis: Acts as a building block for developing novel herbicides, fungicides, and insecticides that require a functionalized piperidine core.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tool compounds for studying biological pathways and target validation.
• Peptidomimetics Development: The piperidine structure is valuable for designing peptidomimetic compounds, where it can mimic amino acid side chains or introduce conformational constraints.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.

Basic Information

Product Name	tert-Butyl 4-Amino-4-(4-Bromophenyl)Piperidine-1-Carboxylate
CAS No.	917925-62-3
Molecular Formula	C16H23BrN2O2
Molecular Weight	355.27 g/mol
Synonyms	1-Boc-4-Amino-4-(4-bromophenyl)piperidine; 4-Amino-4-(4-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-amino-4-(p-bromophenyl)piperidine-1-carboxylate; 4-(4-Bromophenyl)-4-aminopiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-amino-4-(4-bromophenyl)piperidine; 4-Amino-4-(4-bromophenyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 917925-62-3; 4-(4-Bromophenyl)-4-aminopiperidine-1-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-4-(4-Bromophenyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), impurity profile, and physical characteristics is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.