Description

4-[(2-Aminoethyl)Sulfonyl]-1-Boc-Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide and Boc-protected piperazine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with potential therapeutic applications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex drug candidates, particularly in areas like kinase inhibitor and protease inhibitor discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds, particularly for targets requiring a sulfonamide-linked basic amine moiety.
• Protease & Kinase Inhibitor Development: Serves as a core scaffold or linker in the design of potential enzyme inhibitors.
• Peptidomimetic Synthesis: Incorporated into peptide-like structures to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects at gram to kilogram scale under cGMP or non-GMP conditions.

Basic Information

Product Name	4-[(2-Aminoethyl)Sulfonyl]-1-Boc-Piperazine
CAS No.	917562-08-4
Molecular Formula	C11H23N3O4S
Molecular Weight	293.38 g/mol
Synonyms	1-Boc-4-[(2-Aminoethyl)Sulfonyl]Piperazine; tert-Butyl 4-(2-aminoethylsulfonyl)piperazine-1-carboxylate; 4-(2-Aminoethanesulfonyl)-1-(tert-butoxycarbonyl)piperazine; N-Boc-4-(2-aminoethylsulfonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-[(2-aminoethyl)sulfonyl]piperazine; 4-(2-Aminoethylsulfonyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-4-(2-aminoethylsulfone)
EINECS	Contact for details

Quality Control

Our 4-[(2-Aminoethyl)Sulfonyl]-1-Boc-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment. We support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.