Description

(R)-1-Methyl-4-(Pyrrolidin-3-Yl)Piperazine Trihydrochloride is a high-purity chiral piperazine derivative, a crucial building block in modern pharmaceutical research and development. Its primary value lies in its role as a sophisticated intermediate for synthesizing active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require enantiomerically pure intermediates to develop novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical precursor in the multi-step synthesis of complex, enantiomerically pure APIs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable, GMP-compliant manufacturing routes for clinical and commercial drug substances.
• Ligand Synthesis: Can be utilized in the preparation of chiral ligands for asymmetric catalysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(R)-1-Methyl-4-(Pyrrolidin-3-Yl)Piperazine Trihydrochloride
CAS No.	917505-14-7
Molecular Formula	C9H22Cl3N3
Molecular Weight	278.65 g/mol
Synonyms	(R)-1-Methyl-4-(3-pyrrolidinyl)piperazine trihydrochloride; (R)-1-Methyl-4-(pyrrolidin-3-yl)piperazine hydrochloride (1:3); (3R)-1-Methyl-4-(3-pyrrolidinyl)piperazine trihydrochloride; (R)-N-Methyl-4-(3-pyrrolidinyl)piperazine trihydrochloride; 1-Methyl-4-[(3R)-pyrrolidin-3-yl]piperazine trihydrochloride; (R)-1-Methyl-4-(3-pyrrolidinyl)piperazine 3HCl
EINECS	Contact for details

Quality Control

Our (R)-1-Methyl-4-(Pyrrolidin-3-Yl)Piperazine Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.