Description

4-(4-Methyl-1-Piperazinyl)-n-[1,4,5,6-Tetrahydro-5-[(2S)-2-Methoxy-2-Phenylacetyl]Pyrrolo[3,4-C]Pyrazol-3-Yl]Benzamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• API Development: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Biochemical Research: Potential tool compound for investigating specific biological pathways and protein interactions in vitro.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Used in university and institutional labs for pioneering research in organic synthesis and drug discovery methodologies.

Basic Information

Item	Details
Product Name	4-(4-Methyl-1-Piperazinyl)-n-[1,4,5,6-Tetrahydro-5-[(2S)-2-Methoxy-2-Phenylacetyl]Pyrrolo[3,4-C]Pyrazol-3-Yl]Benzamide
CAS No.	916995-51-2
Molecular Formula	C27H30N6O3
Molecular Weight	486.57 g/mol
Synonyms	4-(4-Methylpiperazin-1-yl)-N-(1,4,5,6-tetrahydro-5-[(2S)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl)benzamide; (S)-4-(4-Methylpiperazin-1-yl)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrazol-3-yl)benzamide; UNII-8JQ5607E6I; 8JQ5607E6I; Benzamide, 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2S)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]-; Aprepitant Intermediate; CAS 916995-51-2
EINECS	Contact for details

Quality Control

Our 4-(4-Methyl-1-Piperazinyl)-n-[1,4,5,6-Tetrahydro-5-[(2S)-2-Methoxy-2-Phenylacetyl]Pyrrolo[3,4-C]Pyrazol-3-Yl]Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.