Description

2-Bromo-6-Chloropyrazine is a high-purity halogenated pyrazine derivative, a crucial building block in advanced organic synthesis. Its value lies in its dual reactive sites, which enable precise and versatile functionalization for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrazine core's bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the bromo and chloro substituents.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for drug discovery programs.
• Ligand and Catalyst Preparation: Used to synthesize specialized chelating ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Bromo-6-Chloropyrazine
CAS No.	916791-07-6
Molecular Formula	C4H2BrClN2
Molecular Weight	193.43 g/mol
Synonyms	6-Chloro-2-bromopyrazine; 2-Bromo-6-chloro-1,4-diazine; Pyrazine, 2-bromo-6-chloro-; 2-Bromo-6-chloropyrazine; 916791-07-6; Bromochloropyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Chloropyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; ensure the container is kept sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.