Description

5-Acetylpyrazine-2-Carbonitrile is a versatile and high-purity heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both acetyl and nitrile functional groups on a pyrazine core, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the pyrazine scaffold's bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as components for OLEDs or conductive polymers.
• Flavor and Fragrance Industry: Acts as a potential intermediate for synthesizing complex aroma chemicals due to the pyrazine ring's nutty, roasted flavor characteristics.
• Academic & Contract Research: A valuable reagent for methodological studies in heterocyclic chemistry and the construction of molecular libraries for high-throughput screening.

Basic Information

Product Name	5-Acetylpyrazine-2-Carbonitrile
CAS No.	916333-43-2
Molecular Formula	C7H5N3O
Molecular Weight	147.14 g/mol
Synonyms	2-Cyano-5-acetylpyrazine; 1-(5-Cyano-2-pyrazinyl)ethanone; 5-Acetyl-2-cyanopyrazine; 5-Acetylpyrazine-2-carbonitrile; Ethanone, 1-(5-cyano-2-pyrazinyl)-; 2-Pyrazinecarbonitrile, 5-acetyl-
EINECS	Contact for details

Quality Control

Every batch of 5-Acetylpyrazine-2-Carbonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with options for higher grades (≥98%, ≥99%) available to support critical R&D and scale-up activities. A detailed Certificate of Analysis (COA) providing full chromatographic and spectroscopic data is supplied with each shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.