Description

Naveglitazar (Racemate) CAS NO 916085-47-7 is a high-purity chemical reference standard of a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist. This compound is of significant value for pharmaceutical research and development, serving as a critical intermediate or active pharmaceutical ingredient (API) impurity standard. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in metabolic disease drug discovery, analytical method development, and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of Naveglitazar and its related substances in drug substances and products.
• Metabolic Disease Research: Serves as a key pharmacological tool in preclinical studies targeting Type 2 diabetes and dyslipidemia via PPAR pathway modulation.
• Analytical Method Development: Essential for developing and validating chromatographic methods (HPLC, LC-MS) for purity and impurity profiling in API manufacturing.
• Process Chemistry & Impurity Synthesis: Used as a starting material or intermediate in the synthesis of specific stereoisomers or for generating impurity markers for regulatory filings.
• Quality Control & Assurance: Critical for in-house QC laboratories to ensure the identity, strength, quality, and purity of drug batches against a known racemate standard.

Basic Information

Product Name	Naveglitazar (Racemate)
CAS No.	916085-47-7
Molecular Formula	C₁₈H₁₆N₂O₅S
Molecular Weight	372.40 g/mol
Synonyms	MBX-102; MBX-102 Acid; JTT-501; (RS)-Naveglitazar; (±)-Naveglitazar; 4-[[(2S,4S)-2-(4-Methoxyphenyl)-4-thiazolidinyl]methoxy]benzoic Acid (racemate); 4-[[(2RS,4RS)-2-(4-Methoxyphenyl)-1,3-thiazolidin-4-yl]methoxy]benzoic Acid
EINECS	Contact for details

Quality Control

Our Naveglitazar (Racemate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.