Description

1-Fmoc-Piperazine-2-(S)-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a piperazine ring and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, nitrogen-rich structural motifs. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the controlled assembly of peptide chains, particularly those requiring a constrained piperazine scaffold.
• Peptidomimetic Drug Discovery: Serves as a versatile intermediate for creating conformationally restricted analogs to enhance metabolic stability and receptor selectivity of lead compounds.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological disorders, oncology, and infectious diseases.
• Chemical Biology Probes: Employed in the design and synthesis of tool compounds and labeled peptides for studying enzyme mechanisms and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse combinatorial libraries focused on nitrogen-containing heterocycles.

Basic Information

Product Name	1-Fmoc-Piperazine-2-(S)-Carboxylic Acid
CAS No.	915749-50-7
Molecular Formula	C₂₁H₂₂N₂O₄
Molecular Weight	366.42 g/mol
Synonyms	(S)-1-((9H-Fluoren-9-yl)methoxy)carbonyl)piperazine-2-carboxylic acid; Fmoc-Pip(2S)-OH; Fmoc-(S)-2-Piperazinecarboxylic Acid; 1-[(9-Fluorenylmethoxy)carbonyl]-(2S)-piperazinecarboxylic Acid; (S)-1-Fmoc-piperazine-2-carboxylic acid; Fmoc-L-Piperazine-2-carboxylic Acid; 1-Fmoc-(S)-piperazine-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-Fmoc-Piperazine-2-(S)-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.