Description

(R)-1-n-Boc-3-Cyano-Piperidine CAS NO 915226-44-7 is a high-purity, chiral piperidine derivative serving as a critical building block in modern organic synthesis. Its value lies in providing a protected, enantiomerically pure nitrogen heterocycle scaffold essential for constructing complex molecules with defined stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where biological activity is enantiomer-dependent.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts.
• Peptidomimetics & Bioactive Molecule Construction: The Boc-protected amine and cyano group offer versatile handles for further functionalization in drug discovery programs.
• Academic & Industrial R&D: Employed in methodological chemistry research for developing new synthetic routes and studying stereochemical outcomes.

Basic Information

Product Name	(R)-1-n-Boc-3-Cyano-Piperidine
CAS No.	915226-44-7
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-cyanopiperidine; (R)-3-Cyano-1-Boc-piperidine; (R)-1-Boc-3-cyano-piperidine; tert-Butyl (R)-3-cyanopiperidine-1-carboxylate; (R)-1-N-Boc-3-cyanopiperidine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidine-3-carbonitrile; (R)-1-Boc-3-cyanopiperidine; (R)-3-Cyano-N-Boc-piperidine
EINECS	Contact for details

Quality Control

Our (R)-1-n-Boc-3-Cyano-Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical and chiral purity, NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.