Description

tert-Butyl 4-(3-Fluoro-2-Nitrophenyl)Piperazine-1-Carboxylate is a high-value, multi-functional piperazine derivative and a crucial protected intermediate in advanced organic synthesis. Its core value lies in providing a versatile, nitrogen-rich scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key protected precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) by introducing the fluoronitrophenyl-piperazine moiety into candidate molecules.
• Library Synthesis: A valuable building block for generating diverse compound libraries via parallel synthesis and combinatorial chemistry techniques in early-stage drug discovery.
• Agrochemical Development: Employed in the research and synthesis of new generation herbicides, fungicides, and insecticides that utilize complex amine architectures.
• Chemical Biology Probes: Acts as a starting material for creating fluorescent or affinity-labeled probes to study biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4-(3-Fluoro-2-Nitrophenyl)Piperazine-1-Carboxylate
CAS No.	915135-20-5
Molecular Formula	C15H20FN3O4
Molecular Weight	325.34 g/mol
Synonyms	1-Boc-4-(3-Fluoro-2-nitrophenyl)piperazine; tert-Butyl 4-(3-fluoro-2-nitrophenyl)-1-piperazinecarboxylate; 4-(3-Fluoro-2-nitrophenyl)-N-Boc-piperazine; 1-(tert-Butoxycarbonyl)-4-(3-fluoro-2-nitrophenyl)piperazine; N-Boc-3-fluoro-2-nitrophenylpiperazine; Boc-4-(3-Fluoro-2-nitrophenyl)piperazine; 915135-20-5; Piperazine, 1-(1,1-dimethylethyl) 4-(3-fluoro-2-nitrophenyl)-, 1,4-dicarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Fluoro-2-Nitrophenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening a new container to maximize shelf life. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.