Description

Protected U-U 5’-Cep is a specialized nucleoside phosphoramidite derivative, a critical building block in oligonucleotide synthesis. This high-purity intermediate is essential for the automated solid-phase synthesis of DNA and RNA sequences, enabling precise control over genetic material assembly. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in antisense therapy, siRNA development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: As a phosphoramidite monomer for the automated synthesis of DNA and RNA strands in solid-phase synthesizers.
• Therapeutic Nucleic Acid Development: A key raw material for producing antisense oligonucleotides, siRNA, and aptamers for targeted therapies.
• Diagnostic Probe Manufacturing: Used in the production of labeled probes for PCR, qPCR, FISH, and microarray technologies.
• Genomic Research: Enables the custom synthesis of primers, linkers, and gene fragments for cloning and sequencing applications.
• Bioconjugation: Serves as a starting point for creating functionalized oligonucleotides with modifications for detection or targeting.

Basic Information

Product Name	Protected U-U 5’-Cep
CAS No.	915098-72-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(tert-butyldimethylsilyl)]-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[(1,1-dimethylethyl)dimethylsilyl]-3'-[2-cyanoethoxy(diisopropylamino)phosphino]-; DMTr-TBDMS-U-CE Phosphoramidite; U Phosphoramidite (2'-O-TBDMS, DMT); 2'-O-TBDMS-5'-O-DMT-Uridine-3'-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our Protected U-U 5’-Cep CAS NO 915098-72-5 is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and 31P NMR for structural confirmation, to ensure it meets the exacting standards required for sensitive oligonucleotide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and performance data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Moisture (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.