Description

Piperazine, 1-(2-Fluoro-1,1-Dimethylethyl)- is a specialized fluorinated piperazine derivative, a high-value building block in advanced organic synthesis. This compound matters for its unique structural motif, combining the piperazine scaffold with a fluorinated tert-butyl group, which is crucial for modulating the physicochemical and pharmacokinetic properties of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where the introduction of fluorine can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorinated group can improve efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for designing novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	Piperazine, 1-(2-Fluoro-1,1-Dimethylethyl)-
CAS No.	914768-62-0
Molecular Formula	C9H19FN2
Molecular Weight	174.26 g/mol
Synonyms	1-(2-Fluoro-1,1-dimethylethyl)piperazine; 1-(2-Fluoro-2-methylpropyl)piperazine; 2-Fluoro-2-methylpropyl-piperazine; N-(2-Fluoro-1,1-dimethylethyl)piperazine; 1-(1-Fluoro-2-methylpropan-2-yl)piperazine; 2-Fluoro-2-methyl-1-piperazin-1-ylpropane; Fluorinated tert-butyl piperazine
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(2-Fluoro-1,1-Dimethylethyl)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity advanced intermediates for regulated R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.