Description

Exendin-4 (Acetate) is a synthetic 39-amino acid peptide analog of exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist. Its primary value lies in its potent and long-lasting insulinotropic effects, making it a critical compound for metabolic research and therapeutic development. This product is essential for pharmaceutical R&D teams, academic researchers, and manufacturers focused on diabetes, obesity, and related metabolic disorders.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) in the development of novel GLP-1-based therapeutics for Type 2 diabetes and obesity.
• Preclinical & Clinical Studies: Serves as a key biological tool for investigating mechanisms of insulin secretion, β-cell function, and appetite regulation in animal models and human trials.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, ELISA kits, and other diagnostic tools targeting the GLP-1 receptor pathway.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research into endocrinology, peptide pharmacology, and metabolic signaling pathways.
• Process Development & Scale-up: Acts as a benchmark for process chemistry teams optimizing synthesis, purification, and formulation processes for peptide-based drugs.

Basic Information

Product Name	Exendin-4 (Acetate)
CAS No.	914454-01-6
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	Exendin-4 acetate salt; Exenatide acetate; AC 2993; LY2148568; Synthetic Exendin-4; GLP-1 receptor agonist exendin-4; [Ser2]-Exendin-4 (1-39); L-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (acetate)
EINECS	Contact for details

Quality Control

Our Exendin-4 (Acetate) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry (MS) for confirmation, and tests for residual solvents and endotoxins. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	3.0 - 8.0%
Peptide Content	≥ 80.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.