Description

2-Bromo-6-Methylpyrazine CAS NO 914452-71-4 is a high-purity halogenated pyrazine derivative serving as a versatile and critical building block in advanced organic synthesis. Its value lies in providing a reactive bromine substituent on the pyrazine ring, enabling efficient cross-coupling reactions and functional group transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those containing pyrazine cores for antiviral, anticancer, or central nervous system (CNS) applications.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the bromine atom facilitates the introduction of other functional groups.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in homogeneous catalysis and material science.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for organic light-emitting diodes (OLEDs) or conductive polymers.
• Flavor and Fragrance Chemistry: Acts as an intermediate for synthesizing specific pyrazine-based aroma compounds, though at high purity grades.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry, including Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-Bromo-6-Methylpyrazine
CAS No.	914452-71-4
Molecular Formula	C5H5BrN2
Molecular Weight	173.01 g/mol
Synonyms	6-Methyl-2-bromopyrazine; 2-Bromo-6-methylpyrazine; 2-Bromo-6-methyl-1,4-diazine; Bromo-methylpyrazine; Pyrazine, 2-bromo-6-methyl-; 914452-71-4 (CAS); 2-Br-6-Me-Pyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Methylpyrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and purity while monitoring for specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.