Description

2-Iodo-5-Methylpyrazine is a high-purity halogenated heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a versatile intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling key coupling and functionalization reactions. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its pyrazine core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialized polymers and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings to form new carbon-carbon bonds.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Used to synthesize labeled compounds or probes for studying biological mechanisms and pathways.

Basic Information

Product Name	2-Iodo-5-Methylpyrazine
CAS No.	914452-70-3
Molecular Formula	C5H5IN2
Molecular Weight	220.01 g/mol
Synonyms	5-Methyl-2-iodopyrazine; 2-Iodo-5-methylpyrazine; 5-Methylpyrazin-2-yl iodide; Iodomethylpyrazine; Pyrazine, 2-iodo-5-methyl-; 2-Iodo-5-methyl-1,4-diazine
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-Methylpyrazine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.